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  4. Multiscale fluid-structure interaction simulation of anatomically correct left ventricle fluid dynamics with fictitious elastic structure regularization
 
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Multiscale fluid-structure interaction simulation of anatomically correct left ventricle fluid dynamics with fictitious elastic structure regularization

Lassila, Toni Mikael  
•
Malossi, Adelmo Cristiano Innocenza  
•
Stevanella, Marco
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2012

We propose a new approach for the data assimilation and simulation of anatomically correct left ventricle fluid dynamics based on cardiac magnetic resonance images. The movement of the ventricle is captured by a set of tracking points on the endocardium identified from a time series of magnetic resonance images. The displacement of the endocardium is interpolated using radial basis functions to produce a smooth global deformation field in both space and time. To regularize the motion of the fluid inside the ventricle we impose the displacement on a fictitious elastic structure surrounding the fluid domain, and then solve the problem in a fluid-structure interaction formulation. This allows to provide physiological flow and pressure levels inside the left ventricle. In order to have physically reasonable outflow conditions, we couple the left ventricle to a network of one-dimensional models, where we can simulate the pressure and flow rate waveforms in the major arteries, thus obtaining a geometrical multiscale model. The end result is a baseline model for the left ventricle that captures the basic fluidic phenomena and that can in the future be extended to consider clinical patient-specific studies by integrating more complex models into the multiscale framework.

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Type
report
Author(s)
Lassila, Toni Mikael  
Malossi, Adelmo Cristiano Innocenza  
Stevanella, Marco
Votta, Emiliano
Redaelli, Alberto
Deparis, Simone  
Date Issued

2012

Publisher

Wiley InterScience

Total of pages

23

Subjects

left ventricle

•

fluid-structure interaction

•

data assimilation

•

patient-specific modeling

•

multiscale model

Written at

EPFL

EPFL units
CMCS  
SCI-SB-SD  
Available on Infoscience
September 14, 2012
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/85394
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