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  4. Multiscale fluid-structure interaction simulation of anatomically correct left ventricle fluid dynamics with fictitious elastic structure regularization
 
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Multiscale fluid-structure interaction simulation of anatomically correct left ventricle fluid dynamics with fictitious elastic structure regularization

Lassila, Toni Mikael  
•
Malossi, Adelmo Cristiano Innocenza  
•
Stevanella, Marco
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2012

We propose a new approach for the data assimilation and simulation of anatomically correct left ventricle fluid dynamics based on cardiac magnetic resonance images. The movement of the ventricle is captured by a set of tracking points on the endocardium identified from a time series of magnetic resonance images. The displacement of the endocardium is interpolated using radial basis functions to produce a smooth global deformation field in both space and time. To regularize the motion of the fluid inside the ventricle we impose the displacement on a fictitious elastic structure surrounding the fluid domain, and then solve the problem in a fluid-structure interaction formulation. This allows to provide physiological flow and pressure levels inside the left ventricle. In order to have physically reasonable outflow conditions, we couple the left ventricle to a network of one-dimensional models, where we can simulate the pressure and flow rate waveforms in the major arteries, thus obtaining a geometrical multiscale model. The end result is a baseline model for the left ventricle that captures the basic fluidic phenomena and that can in the future be extended to consider clinical patient-specific studies by integrating more complex models into the multiscale framework.

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Type
report
Author(s)
Lassila, Toni Mikael  
•
Malossi, Adelmo Cristiano Innocenza  
•
Stevanella, Marco
•
Votta, Emiliano
•
Redaelli, Alberto
•
Deparis, Simone  
Date Issued

2012

Publisher

Wiley InterScience

Total of pages

23

Subjects

left ventricle

•

fluid-structure interaction

•

data assimilation

•

patient-specific modeling

•

multiscale model

Written at

EPFL

EPFL units
CMCS  
SCI-SB-SD  
Available on Infoscience
September 14, 2012
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/85394
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