research article
Synthesis of alpha-C(1 -> 3)-mannopyranoside of N-acetylgalactosamine, a new beta-galactosidase inhibitor
Radical C-glycosidation of a 3-methylidene-7-oxabicyclo[2.2.1]heptan-2-one derivative with acetobromomannose gave a alpha-C-mannopyranoside that was converted into alpha-D-ManpCH(2)(1-->3)-D-GalNAc, a C-disaccharide that inhibits beta-galactosidase from jack bean with IC50 = 9.4 mu M and K-i = 7.5 mu M (mixed mode of inhibition). (C) 1999 Elsevier Science Ltd. All rights reserved.
Type
research article
Author(s)
Date Issued
1999
Published in
Volume
9
Issue
5
Start page
793
End page
796
Note
Univ Lausanne, Inst Chim Organ, BCH, CH-1015 Lausanne, Switzerland.
Editorial or Peer reviewed
REVIEWED
Written at
EPFL
EPFL units
Available on Infoscience
November 9, 2005
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