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research article

Ultrafast-based projection-reconstruction three-dimensional nuclear magnetic resonance spectroscopy

Mishkovsky, Mor  
•
Kupče, Eriks
•
Frydman, Lucio
2007
The Journal of Chemical Physics

Recent years have witnessed increased efforts toward the accelerated acquisition of multidimensional nuclear magnetic resonance (nD NMR) spectra. Among the methods proposed to speed up these NMR experiments is "projection reconstruction," a scheme based on the acquisition of a reduced number of two-dimensional (2D) NMR data sets constituting cross sections of the nD time domain being sought. Another proposition involves "ultrafast" spectroscopy, capable of completing nD NMR acquisitions within a single scan. Potential limitations of these approaches include the need for a relatively slow 2D-type serial data collection procedure in the former case, and a need for at least n high-performance, linearly independent gradients and a sufficiently high sensitivity in the latter. The present study introduces a new scheme that comes to address these limitations, by combining the basic features of the projection reconstruction and the ultrafast approaches into a single, unified nD NMR experiment. In the resulting method each member within the series of 2D cross sections required by projection reconstruction to deliver the nD NMR spectrum being sought, is acquired within a single scan with the aid of the 2D ultrafast protocol. Full nD NMR spectra can thus become available by backprojecting a small number of 2D sets, collected using a minimum number of scans. Principles, opportunities, and limitations of the resulting approach, together with demonstrations of its practical advantages, are here discussed and illustrated with a series of three-dimensional homo- and heteronuclear NMR correlation experiments. (C) 2007 American Institute of Physics.

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Type
research article
DOI
10.1063/1.2748768
Author(s)
Mishkovsky, Mor  
Kupče, Eriks
Frydman, Lucio
Date Issued

2007

Publisher

American Institute of Physics

Published in
The Journal of Chemical Physics
Volume

127

Issue

3

Article Number

034507

Editorial or Peer reviewed

NON-REVIEWED

Written at

EPFL

EPFL units
IPSB  
Available on Infoscience
September 25, 2013
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/94928
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