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review article

Stochastic thermodynamics for biological functions

Cao, Yuansheng
•
Liang, Shiling  
March 1, 2025
Quantitative Biology

Living systems operate within physical constraints imposed by nonequilibrium thermodynamics. This review explores recent advancements in applying these principles to understand the fundamental limits of biological functions. We introduce the framework of stochastic thermodynamics and its recent developments, followed by its application to various biological systems. We emphasize the interconnectedness of kinetics and energetics within this framework, focusing on how network topology, kinetics, and energetics influence functions in thermodynamically consistent models. We discuss examples in the areas of molecular machine, error correction, biological sensing, and collective behaviors. This review aims to bridge physics and biology by fostering a quantitative understanding of biological functions.

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Type
review article
DOI
10.1002/qub2.75
Web of Science ID

WOS:001380106200001

Author(s)
Cao, Yuansheng

Tsinghua University

Liang, Shiling  

École Polytechnique Fédérale de Lausanne

Date Issued

2025-03-01

Publisher

WILEY

Published in
Quantitative Biology
Article Number

e75

Subjects

NONEQUILIBRIUM

•

ULTRASENSITIVITY

•

AMPLIFICATION

•

DISSIPATION

•

SENSITIVITY

•

SYSTEMS

•

LIMITS

•

INFORMATION

•

MECHANISM

•

PROTEINS

•

biological functions

•

physical constraints

•

stochastic thermodynamics

•

Science & Technology

•

Life Sciences & Biomedicine

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LBS  
FunderFunding(s)Grant NumberGrant URL

National Natural Science Foundation of China (NSFC)

Swiss National Science Foundation (SNSF)

200020_178763

Available on Infoscience
January 27, 2025
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/245417
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