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  4. Palladium(II)-Stabilized Pyridine-2-Diazotates: Synthesis, Structural Characterization, and Cytotoxicity Studies
 
research article

Palladium(II)-Stabilized Pyridine-2-Diazotates: Synthesis, Structural Characterization, and Cytotoxicity Studies

Tskhovrebov, Alexander G.  
•
Vasileva, Anna A.
•
Goddard, Richard
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2018
Inorganic Chemistry

Well-defined diazotates are scarce. Here we report the synthesis of unprecedented homoleptic palladium(II) diazotate complexes. The palladium(II)-mediated nitrosylation of 2-aminopyridines with NaNO2 results in the formation of metal-stabilized diazotates, which were found to be cytotoxic to human ovarian cancer cells.

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Type
research article
DOI
10.1021/acs.inorgchem.8b00072
Web of Science ID

WOS:000424730800008

Author(s)
Tskhovrebov, Alexander G.  
Vasileva, Anna A.
Goddard, Richard
Riedel, Tina
Dyson, Paul J.
Mikhaylov, Vladimir N.
Serebryanskaya, Tatiyana V.
Sorokoumov, Viktor N.
Haukka, Matti
Date Issued

2018

Published in
Inorganic Chemistry
Volume

57

Issue

3

Start page

930

End page

934

Subjects

carcinogen n-nitrosomorpholine

•

nitrous-oxide

•

pyrazine diazohydroxide

•

heterocyclic carbenes

•

ligand release

•

complexes

•

palladium

•

chemistry

•

nitrosamines

•

mutagenicity

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LCOM  
Available on Infoscience
July 11, 2018
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/147226
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