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  4. An integrated heart-torso electromechanical model for the simulation of electrophysiological outputs accounting for myocardial deformation
 
research article

An integrated heart-torso electromechanical model for the simulation of electrophysiological outputs accounting for myocardial deformation

Zappon, Elena
•
Salvador, Matteo
•
Piersanti, Roberto
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July 1, 2024
Computer Methods In Applied Mechanics And Engineering

When generating in-silico clinical electrophysiological outputs, such as electrocardiograms (ECGs) and body surface potential maps (BSPMs), mathematical models have relied on single physics, i.e. of the cardiac electrophysiology (EP), neglecting the role of the heart motion. Since the heart is the most powerful source of electrical activity in the human body, its motion dynamically shifts the position of the principal electrical sources in the torso, influencing electrical potential distribution and potentially altering the EP outputs. In this work, we propose a computational model for the simulation of ECGs and BSPMs by coupling a cardiac electromechanical model with a model that simulates the propagation of the EP signal in the torso, thanks to a flexible numerical approach, that simulates the torso domain deformation induced by the myocardial displacement. Our model accounts for the major mechano-electrical feedbacks, along with unidirectional displacement and potential couplings from the heart to the surrounding body. For the numerical discretization, we employ a versatile intergrid transfer operator that allows for the use of different Finite Element spaces to be used in the cardiac and torso domains. Our numerical results are obtained on a realistic 3D biventricular-torso geometry, and cover both cases of sinus rhythm and ventricular tachycardia (VT), solving both the electromechanical -torso model in dynamical domains, and the classical electrophysiologytorso model in static domains. By comparing standard 12 -lead ECG and BSPMs, we highlight the non -negligible effects of the myocardial contraction on the EP -outputs, especially in pathological conditions, such as the VT.

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Type
research article
DOI
10.1016/j.cma.2024.117077
Web of Science ID

WOS:001248530000001

Author(s)
Zappon, Elena
Salvador, Matteo
Piersanti, Roberto
Regazzoni, Francesco
Dede, Luca
Quarteroni, Alfio  
Date Issued

2024-07-01

Publisher

Elsevier Science Sa

Published in
Computer Methods In Applied Mechanics And Engineering
Volume

427

Article Number

117077

Subjects

Technology

•

Physical Sciences

•

Heart-Torso Model

•

Electrocardiograms

•

Cardiac Electromechanics

•

Multiphysics Modeling

•

Body Surface Potential Maps

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
CIB  
FunderGrant Number

INdAM-GNCS

CUP E53C22001930001

MUR, Italy

202232A8AN

Available on Infoscience
July 3, 2024
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/209087
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