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research article

Impact of atrial fibrillation on left atrium haemodynamics: A computational fluid dynamics study

Corti, Mattia
•
Zingaro, Alberto
•
Dede', Luca  
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November 1, 2022
Computers In Biology And Medicine

We analyse the haemodynamics of the left atrium, highlighting differences between healthy individuals and patients affected by atrial fibrillation. The computational study is based on patient-specific geometries of the left atria to simulate blood flow dynamics. We design a novel procedure to compute the boundary data for the 3D haemodynamic simulations, which are particularly useful in absence of data from clinical measurements. With this aim, we introduce a parametric definition of atrial displacement, and we use a closed-loop lumped parameter model of the whole cardiovascular circulation conveniently tuned on the basis of the patient's characteristics. We evaluate several fluid dynamics indicators for atrial haemodynamics, validating our numerical results in terms of clinical measurements; we investigate the impact of geometric and clinical characteristics on the risk of thrombosis. To highlight the correlation of thrombus formation with atrial fibrillation, according to medical evidence, we propose a novel indicator: age stasis. It arises from the combination of Eulerian and Lagrangian quantities. This indicator identifies regions where slow flow cannot properly rinse the chamber, accumulating stale blood particles, and creating optimal conditions for clots formation.

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Type
research article
DOI
10.1016/j.compbiomed.2022.106143
Web of Science ID

WOS:000869635300001

Author(s)
Corti, Mattia
Zingaro, Alberto
Dede', Luca  
Quarteroni, Alfio Maria
Date Issued

2022-11-01

Publisher

PERGAMON-ELSEVIER SCIENCE LTD

Published in
Computers In Biology And Medicine
Volume

150

Article Number

106143

Subjects

Biology

•

Computer Science, Interdisciplinary Applications

•

Engineering, Biomedical

•

Mathematical & Computational Biology

•

Life Sciences & Biomedicine - Other Topics

•

Computer Science

•

Engineering

•

computational fluid dynamics

•

cardiac modelling

•

left atrium haemodynamics

•

atrial fibrillation

•

left atrial appendage

•

4d flow mri

•

cardiovascular-system

•

adult patients

•

blood stasis

•

velocity

•

echocardiography

•

association

•

bifurcation

•

mechanisms

•

pressures

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
CMCS  
Available on Infoscience
November 7, 2022
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/191909
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