Laminar analysis of the cerebellar cortex shows widespread damage in early MS patients: A pilot study at 7T MRI
Background To date, little is known about the presence and extent of cerebellar cortical pathology in early stages of MS.
Objective The aims of this study were to (i) investigate microstructural changes in the normal-appearing cerebellar cortex of early MS patients by using 7T MRI and (ii) evaluate the influence of those changes on clinical performance.
Methods Eighteen RRMS patients and nine healthy controls underwent quantitative T-1 and T-2* measurement at 7T MRI using high-resolution MP2RAGE and multi-echo gradient-echo imaging. After subtracting lesion masks, average T-1 and T-2* maps were computed for three layers in the cerebellar cortex and compared between groups using mixed effects models.
Results The volume of the cerebellar cortex and its layers did not differ between patients and controls. In MS patients, significantly longer T-1 values were observed in all vermis cortical layers and in the middle and external cortical layer of the cerebellar hemispheres. No between-group differences in T-2* values were found. T-1 values correlated with EDSS, SDMT and PASAT.
Conclusions We found MRI evidence of damage in the normal-appearing cerebellar cortex at early MS stages and before volumetric changes. This microstructural alteration appears to be related to EDSS and cognitive performance.
WOS:000679127600006
2020-10-01
6
4
2055217320961409
REVIEWED