In this Letter, we address the question of whether the conformal invariance can be considered as a global symmetry of a theory of fundamental interactions. To describe Nature, this theory must contain a mechanism of spontaneous breaking of the scale symmetry. Besides that, the fundamental theory must include gravity, whereas all known extensions of the conformal invariance to the curved space-time suffer from the Weyl anomaly. We show that conformal symmetry can be made free from quantum anomaly only in flat space. The presence of gravity would reduce the global symmetry group of the fundamental theory to the scale invariance only. We discuss how the effective Lagrangian respecting the scale symmetry can be used for the description of particle phenomenology and cosmology.(c) 2023 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons .org /licenses /by /4 .0/). Funded by SCOAP3.