A computing system that uses a Scale-Out NUMA (“soNUMA”) architecture, programming model, and/or communication protocol provides for low-latency, distributed in-memory processing. Using soNUMA, a programming model is layered directly on top of a NUMA memory fabric via a stateless messaging protocol. To facilitate interactions between the application, OS, and the fabric, soNUMA uses a remote memory controller—an architecturally-exposed hardware block integrated into the node's local coherence hierarchy.