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research article
Copper-Catalyzed 1,2-Addition of alpha-Carbonyl Iodides to Alkynes
beta,gamma,-Unsaturated ketones are an important class of organic molecules. Herein, copper catalysis has been developed for the synthesis of --unsaturated ketones through 1,2-addition of -carbonyl iodides to alkynes. The reactions exhibit wide substrate scope and high functional group tolerance. The reaction products are versatile synthetic intermediates to complex small molecules. The method was applied for the formal synthesis of (+/-)-trichostatinA, a histone deacetylase inhibitor.
Type
research article
Web of Science ID
WOS:000348372900045
Publication date
2015
Publisher
Published in
Volume
54
Issue
4
Start page
1307
End page
1311
Peer reviewed
REVIEWED
Written at
EPFL
EPFL units
Available on Infoscience
May 29, 2015
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