Modulation of chromatin structure has long been proposed to underlie the colinear regulation of Hox genes during animal development. In a recent paper, Chambeyron and Bickmore explore this possibility in retinoic acid-induced ES cells. They show that, while chromatin remodeling confers transcriptional competence to the gene cluster, subsequent sequential extrusion of genes from their chromosome territory may determine their coordinated expression in time
Type
review article
Author(s)
Deschamps, J.
Date Issued
2004
Published in
Volume
6
Issue
6
Start page
738
End page
740
Note
Department of Zoology and Animal Biology and National Program "Frontiers in Genetics", University of Geneva, CH-1211 Geneva, Switzerland
Editorial or Peer reviewed
REVIEWED
Written at
OTHER
EPFL units
Available on Infoscience
February 27, 2008
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