The prediction of the critical buckling conditions of shell structures is plagued by imperfection sensitivity. Non-destructive testing through point-load probing has been recently proposed to map the stability landscape of cylindrical shells. However, the counterpart procedure for spherical shells is still debatable. Here, we focus on the mechanical response of pressurized spherical shells containing a single dimple–like defect to a point probe. Combining experiments, finite element modeling, and existing results from classic shell theory, we characterize the nonlinear force-indentation response of imperfect shells at different pressurization levels. From these curves, we seek to identify the critical buckling pressure of the shell. In particular, the indentation angle is varied systematically to examine its effect on the probing efficacy. We find that the critical buckling point can be inferred non-destructively by tracking the maxima of the indentation force–displacement curves, if the probe is implemented sufficiently close to the defect. When probing further away from the defect, the test fails in predicting the onset of buckling since the deformation due to indentation remains localized in the vicinity of the probe. Using FEM simulations and shallow shell theory, we quantify the characteristic length associated with this localized deformation, both in the linear and nonlinear regimes. Our results demonstrate the limiting conditions of applicability for the usage of probing as a non-destructive technique to assess the stability of spherical shells.