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  4. A Drug Release Mechanism Controlled by Hydrophobic/Hydrophilic Balance of the Matrix. Theoretical and Experimental Perspectives
 
research article

A Drug Release Mechanism Controlled by Hydrophobic/Hydrophilic Balance of the Matrix. Theoretical and Experimental Perspectives

Himiniuc, Loredana
•
Agop, Maricel
•
Ghizdovat, Vlad
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December 1, 2020
Materiale Plastice

Controlled drug release is a promising pathway of biomedicine, meant to suppress side effects with the aim of increasing patient's comfort. A route to achieve this goal represents the encapsulation of drugs into matrixes, capable to develop physical forces, which further can control the drugs release. To this purpose, mathematical modeling is an important tool, which offers the possibility to understand the drug release mechanisms and to further design new performant systems. In this paper, a theoretical model for drug release from an amphiphilic matrix is presented. This is achieved using a conservation multifractal law of probability density followed by validation of the model. Moreover, because nonsteroidal anti-inflammatory drugs (NSAIDs), such as diclofenac, are widely used in endometriosis as painkillers for dysmenorrhea management or Asherman syndrome for reducing the endometrial inflammation, some implications of our model for drug delivery systems applied in the field of gynecology have been discussed.

  • Details
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Type
research article
DOI
10.37358/MP.20.4.5415
Web of Science ID

WOS:000617344900015

Author(s)
Himiniuc, Loredana
Agop, Maricel
Ghizdovat, Vlad
Paun, Maria-Alexandra  
Paun, Vladimir-Alexandru
Baciu, Constantin
Paun, Viorel-Puiu
Toma, Bogdan
Date Issued

2020-12-01

Publisher

REVISTA CHIMIE SRL

Published in
Materiale Plastice
Volume

57

Issue

4

Start page

155

End page

165

Subjects

Materials Science, Multidisciplinary

•

Materials Science

•

controlled drug release

•

drug delivery systems

•

amphiphilic matrix

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nonsteroidal anti-inflammatory drugs

•

diclofenac

•

nonsteroidal antiinflammatory drugs

•

imine-chitosan hydrogels

•

delivery systems

•

fractal analysis

•

transport

•

dimension

•

time

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
SCI-STI-CD  
Available on Infoscience
March 26, 2021
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/176759
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