A communication-centric design approach, Networks on Chips (NoCs), has emerged as the design paradigm for designing a scalable communication infrastructure for future Systems on Chips (SoCs). As technology advances, the number of applications or use-cases integrated on a single chip increases rapidly. The different use-cases of the SoC have different communication requirements (such as different bandwidth, latency constraints) and traffic patterns. The underlying NoC architecture has to satisfy the constraints of all the use-cases. In this work, we present a methodology to map multiple use-cases onto the NoC architecture, satis- fying the constraints of each use-case. We present dynamic re-configuration mechanisms that match the NoC configura- tion to the communication characteristics of each use-case, also accounting for use-cases that can run in parallel. The methodology is applied to several real and synthetic SoC benchmarks, which result in a large reduction in NoC area (an average of 80%) and power consumption (an average of 54%) compared to traditional design approaches.