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research article

Computational study of the risk of restenosis in coronary bypasses

Guerciotti, Bruno
•
Vergara, Christian
•
Ippolito, Sonia
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2017
Biomechanics And Modeling In Mechanobiology

Coronary artery disease, caused by the buildup of atherosclerotic plaques in the coronary vessel wall, is one of the leading causes of death in the world. For high-risk patients, coronary artery bypass graft is the preferred treatment. Despite overall excellent patency rates, bypasses may fail due to restenosis. In this context, the purpose of this work was to perform a parametric computational study of the fluid dynamics in patient-specific geometries with the aim of investigating a possible relationship between coronary stenosis degree and risk of graft failure. Firstly, we propose a strategy to prescribe realistic boundary conditions in the absence of measured data, based on an extension of Murray's law to provide the flow division at bifurcations in case of stenotic vessels and non-Newtonian blood rheology. Then, we carry out numerical simulations in three patients affected by severe coronary stenosis and treated with a graft, in which the stenosis degree is virtually varied in order to compare the resulting fluid dynamics in terms of hemodynamic indices potentially involved in restenosis development. Our findings suggest that low degrees of coronary stenosis produce a more disturbed fluid dynamics in the graft, resulting in hemodynamic conditions that may promote a higher risk of graft failure.

  • Details
  • Metrics
Type
research article
DOI
10.1007/s10237-016-0818-x
Web of Science ID

WOS:000394153400022

Author(s)
Guerciotti, Bruno
Vergara, Christian
Ippolito, Sonia
Quarteroni, Alfio  
Antona, Carlo
Scrofani, Roberto
Date Issued

2017

Publisher

Springer Heidelberg

Published in
Biomechanics And Modeling In Mechanobiology
Volume

16

Issue

1

Start page

313

End page

332

Subjects

Coronary bypass

•

Restenosis

•

Murray's law

•

Non-Newtonian rheology

•

Computational fluid dynamics

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
CMCS  
Available on Infoscience
March 27, 2017
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/135893
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