The human interferon (IFN) gamma receptor cDNA has been stably expressed in human/mouse somatic cell hybrids, which differ in their content of human chromosome 21. Despite high affinity IFN gamma binding-capacity of all receptor transfectants, biological responsiveness to IFN gamma, as determined by enhancement of mouse-MHC class I gene expression, required the presence of chromosome 21. These data suggest complementation of at least two functionally distinct components in order to create a biologically active IFN gamma receptor.
Type
research article
Author(s)
Date Issued
1990
Published in
Volume
2
Issue
3
Start page
157
End page
61
Note
Clinical Research Group, Max-Planck-Society, Klinische Arbeitsgruppe, Gottingen, F.R. Germany.
Editorial or Peer reviewed
REVIEWED
Written at
OTHER
EPFL units
Available on Infoscience
December 12, 2007
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