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research article
Synthesis of diphenoxyadamantane alkylamines with pharmacological interest
June 1, 2019
In this work, the synthesis and the pharmacological evaluation of diphenoxyadamantane alkylamines Ia-f and IIa-f is described. The new diphenoxy-substituted adamantanes share structural features present in trypanocidal and antitubercular agents. 1-Methylpiperazine derivative Ia is the most potent against T. brucei compound, whilst its hexylamine congener IIf exhibits a significant antimycobacterial activity.
Type
research article
Web of Science ID
WOS:000465546100004
Authors
Georgiadis, Markos-Orestis
•
Kourbeli, Violeta
•
Ioannidou, Vaya
•
Karakitsios, Evangelos
•
Papanastasiou, Ioannis
•
Tsotinis, Andrew
•
Komiotis, Dimitri
•
•
•
Taylor, Martin C.
Publication date
2019-06-01
Publisher
Published in
Volume
29
Issue
11
Start page
1278
End page
1281
Peer reviewed
REVIEWED
Written at
EPFL
Available on Infoscience
June 18, 2019
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