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  4. Notch signaling in the pigmented epithelium of the anterior eye segment promotes ciliary body development at the expense of iris formation
 
research article

Notch signaling in the pigmented epithelium of the anterior eye segment promotes ciliary body development at the expense of iris formation

Sarode, Bhushan  
•
Nowell, Craig S.
•
Ihm, JongEun
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2014
Pigment cell & melanoma research

The ciliary body and iris are pigmented epithelial structures in the anterior eye segment that function to maintain correct intra-ocular pressure and regulate exposure of the internal eye structures to light, respectively. The cellular and molecular factors that mediate the development of the ciliary body and iris from the ocular pigmented epithelium remain to be fully elucidated. Here, we have investigated the role of Notch signaling during the development of the anterior pigmented epithelium by using genetic loss- and gain-of-function approaches. Loss of canonical Notch signaling results in normal iris development but absence of the ciliary body. This causes progressive hypotony and over time leads to phthisis bulbi, a condition characterized by shrinkage of the eye and loss of structure/function. Conversely, Notch gain-of-function results in aniridia and profound ciliary body hyperplasia, which causes ocular hypertension and glaucoma-like disease. Collectively, these data indicate that Notch signaling promotes ciliary body development at the expense of iris formation and reveals novel animal models of human ocular pathologies.

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Type
research article
DOI
10.1111/pcmr.12236
Web of Science ID

WOS:000337619700011

Author(s)
Sarode, Bhushan  
Nowell, Craig S.
Ihm, JongEun
Kostic, Corinne
Arsenijevic, Yvan
Moulin, Alexandre P.
Schorderet, Daniel F.
Beermann, Friedrich  
Radtke, Freddy  
Date Issued

2014

Publisher

Wiley-Blackwell

Published in
Pigment cell & melanoma research
Volume

27

Issue

4

Start page

580

End page

9

Subjects

Notch

•

ciliary body

•

ocular hypertension

•

phthisis bulbi

•

glaucoma

•

pigmented epithelium

•

iris

Editorial or Peer reviewed

NON-REVIEWED

Written at

EPFL

EPFL units
GR-BEERMANN  
UPRAD  
Available on Infoscience
March 26, 2014
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/102211
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