For low-emission, small-scale combined heat and power generation, integrating a biomass gasifier with a downstream solid oxide fuel cell system is very promising due to their similar operating conditions in terms of temperatures and pressures. This match avoids intermediate high-temperature heat exchangers and improves system efficiency. However, to couple both systems, a high-temperature and oil-free compressor is required to compress and push the low-density, high-temperature bio-syngas from the gasifier to the solid oxide fuel cell stack. The design and development of this high-temperature, high-speed, and gas-bearing supported compressor is presented in this work. An iterative process involving preliminary design, meanline analysis using commercial tools and in-house models is used for the design, which is then numerically analyzed using computational fluid dynamics. The goal is to achieve a design with a wide operating range and high robustness that withstands extreme working conditions. The 727 W machine is designed to run up to 210 krpm to compress 18.23kgh−1 of syngas at 350°C and 0.81bar. The centrifugal compressor has a tip diameter of 38 mm and consists of 9 backswept main and splitter blades. The impeller is made of Ti6Al4V and coated to prevent hydrogen embrittlement from the hot and highly reactive bio-syngas. The results obtained from the established models suggest a good concordance with the results from numerical analyses, despite the high temperatures and small scale of this design.