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research article

The consensus molecular subtypes of colorectal cancer

Guinney, Justin
•
Dienstmann, Rodrigo
•
Wang, Xin
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2015
Nature Medicine

Colorectal cancer (CRC) is a frequently lethal disease with heterogeneous outcomes and drug responses. To resolve inconsistencies among the reported gene expression-based CRC classifications and facilitate clinical translation, we formed an international consortium dedicated to large-scale data sharing and analytics across expert groups. We show marked interconnectivity between six independent classification systems coalescing into four consensus molecular subtypes (CMSs) with distinguishing features: CMS1 (microsatellite instability immune, 14%), hypermutated, microsatellite unstable and strong immune activation; CMS2 (canonical, 37%), epithelial, marked WNT and MYC signaling activation; CMS3 (metabolic, 13%), epithelial and evident metabolic dysregulation; and CMS4 (mesenchymal, 23%), prominent transforming growth factor-beta activation, stromal invasion and angiogenesis. Samples with mixed features (13%) possibly represent a transition phenotype or intratumoral heterogeneity. We consider the CMS groups the most robust classification system currently available for CRC-with clear biological interpretability-and the basis for future clinical stratification and subtype-based targeted interventions.

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Type
research article
DOI
10.1038/nm.3967
Web of Science ID

WOS:000364621200021

Author(s)
Guinney, Justin
•
Dienstmann, Rodrigo
•
Wang, Xin
•
De Reynies, Aurelien
•
Schlicker, Andreas
•
Soneson, Charlotte
•
Marisa, Laetitia
•
Roepman, Paul
•
Nyamundanda, Gift
•
Angelino, Paolo
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Date Issued

2015

Publisher

Nature Publishing Group

Published in
Nature Medicine
Volume

21

Issue

11

Start page

1350

End page

1356

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
CMSO  
Available on Infoscience
February 16, 2016
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/124174
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