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  4. Modeling and analysis of cell differentiation using hybrid systems
 
conference paper

Modeling and analysis of cell differentiation using hybrid systems

Kamgarpour, Maryam  
•
Tomlin, C
June 2010
Proceedings of the 2010 American Control Conference
2010 American Control Conference (ACC 2010)

The capacity of cells to differentiate into specialized types is fundamental to the development of organisms. However, the underlying cell differentiation process is not yet well understood. In this work, we consider cell differentiation resulting from interactions of the Delta and Notch proteins. We model the protein concentration dynamics using switched affine hybrid automata. Applying tools from monotone dynamical system theory, we prove steady-state properties of the model. We also find, by exploiting symmetries in the system, conditions on the model parameters to ensure that the steady-state reached is consistent with biological observations. We conclude that the piecewise affine hybrid model is a good framework for modeling the cell differentiation process because the consistency of the model with biological observations can be analyzed theoretically for cellular networks of arbitrary size.

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Type
conference paper
DOI
10.1109/ACC.2010.5530837
Author(s)
Kamgarpour, Maryam  
Tomlin, C
Date Issued

2010-06

Publisher

IEEE

Publisher place

Baltimore, MD

Published in
Proceedings of the 2010 American Control Conference
ISBN of the book

978-1-4244-7427-1

978-1-4244-7426-4

978-1-4244-7425-7

Start page

4355

End page

4360

Editorial or Peer reviewed

REVIEWED

Written at

OTHER

EPFL units
SYCAMORE  
Event nameEvent placeEvent date
2010 American Control Conference (ACC 2010)

Baltimore, MD

2010-06

Available on Infoscience
December 1, 2021
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/183409
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