This work aims to evaluate the applicability of EDDS (ethylenediamine-N,N'-disuccinic acid) as an iron chelating agent for photo-Fenton treatment of municipal wastewater spiked with organic contaminants at near-neutral pH. A series of laboratory scale experiments are conducted under simulated sunlight in accordance with a central composite experimental design in order to define the most favorable conditions in terms of initial iron concentration (maintaining a molar ratio 1:2 of Fe:EDDS), H2O2 and pH. The system is evaluated in terms of degradation efficiency, H2O2 consumption and iron availability. The simulated system has been compared in terms of degradation efficiency with a 60 L compound parabolic collector (CPC), and significant correlation has been observed. An approach for estimating near-optimal regions of operability is also demonstrated. (C) 2015 Elsevier B.V. All rights reserved.