The integration of nanoscale sensors with microfluidic platforms is a powerful tool for the design of robust biosensing devices that present high reliability and the advantage of a quick data acquisition. In addition, microfluidic based lab-on-a-chip sensors require minute amounts of clinical samples and cancer biosensing products. However, the integration of nanostructures in such more complex configurations may significantly complicate the electrical readout process. The aim of the present work is to develop improved devices for cancer prognosis based on nanofabricated Memristive Biosensors integrated for the first time with a microfluidic structure. The effective readout of the Memristive Biosensors electrical response is enabled through a series of specially designed metal line extensions realized accordingly in order to fully retain the sensing output signal.