Repository logo

Infoscience

  • English
  • French
Log In
Logo EPFL, École polytechnique fédérale de Lausanne

Infoscience

  • English
  • French
Log In
  1. Home
  2. Academic and Research Output
  3. Journal articles
  4. Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans
 
research article

Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans

Remie, Carlijn M. E.
•
Roumans, Kay H. M.
•
Moonen, Michiel P. B.
Show more
August 1, 2020
American Journal Of Clinical Nutrition

Background: Nicotinamide riboside (NR) is an NAD(+) precursor that boosts cellular NAD(+) concentrations. Preclinical studies have shown profound metabolic health effects after NR supplementation.

Objectives: We aimed to investigate the effects of 6 wk NR supplementation on insulin sensitivity, mitochondrial function, and other metabolic health parameters in overweight and obese volunteers.

Methods: A randomized, double-blinded, placebo-controlled, crossover intervention study was conducted in 13 healthy overweight or obese men and women. Participants received 6 wk NR (1000 mg/d) and placebo supplementation, followed by broad metabolic phenotyping, including hyperinsulinemic-euglycemic clamps, magnetic resonance spectroscopy, muscle biopsies, and assessment of ex vivo mitochondrial function and in vivo energy metabolism.

Results: Markers of increased NAD(+) synthesis-nicotinic acid adenine dinucleotide and methyl nicotinamide-were elevated in skeletal muscle after NR compared with placebo. NR increased body fat-free mass (62.65% +/- 2.49% compared with 61.32% +/- 2.58% in NR and placebo, respectively; change: 1.34% +/- 0.50%, P = 0.02) and increased sleeping metabolic rate. Interestingly, acetylcarnitine concentrations in skeletal muscle were increased upon NR (4558 +/- 749 compared with 3025 +/- 316 pmol/mg dry weight in NR and placebo, respectively; change: 1533 +/- 683 pmol/mg dry weight, P = 0.04) and the capacity to form acetylcarnitine upon exercise was higher in NR than in placebo (2.99 +/- 0.30 compared with 2.40 +/- 0.33 mmol/kg wet weight; change: 0.53 +/- 0.21 mmol/kg wet weight, P = 0.01). However, no effects of NR were found on insulin sensitivity, mitochondrial function, hepatic and intramyocellular lipid accumulation, cardiac energy status, cardiac ejection fraction, ambulatory blood pressure, plasma markers of inflammation, or energy metabolism.

Conclusions: NR supplementation of 1000 mg/d for 6 wk in healthy overweight or obese men and women increased skeletal muscle NAD(+) metabolites, affected skeletal muscle acetylcarnitine metabolism, and induced minor changes in body composition and sleeping metabolic rate. However, no other metabolic health effects were observed.

  • Details
  • Metrics
Type
research article
DOI
10.1093/ajcn/nqaa072
Web of Science ID

WOS:000561751100020

Author(s)
Remie, Carlijn M. E.
•
Roumans, Kay H. M.
•
Moonen, Michiel P. B.
•
Connell, Niels J.
•
Havekes, Bas
•
Mevenkamp, Julian
•
Lindeboom, Lucas
•
de Wit, Vera H. W.
•
van de Weijer, Tineke
•
Aarts, Suzanne A. B. M.
Show more
Date Issued

2020-08-01

Publisher

OXFORD UNIV PRESS

Published in
American Journal Of Clinical Nutrition
Volume

112

Issue

2

Start page

413

End page

426

Subjects

Nutrition & Dietetics

•

nicotinamide riboside

•

nad

•

metabolic health

•

insulin sensitivity

•

mitochondrial function

•

acetylcarnitine

•

body composition

•

human

•

obesity

•

ambulatory blood-pressure

•

nad(+)

•

metabolism

•

insulin

•

diet

•

spectroscopy

•

resveratrol

•

risk

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LISP  
Available on Infoscience
September 10, 2020
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/171543
Logo EPFL, École polytechnique fédérale de Lausanne
  • Contact
  • infoscience@epfl.ch

  • Follow us on Facebook
  • Follow us on Instagram
  • Follow us on LinkedIn
  • Follow us on X
  • Follow us on Youtube
AccessibilityLegal noticePrivacy policyCookie settingsEnd User AgreementGet helpFeedback

Infoscience is a service managed and provided by the Library and IT Services of EPFL. © EPFL, tous droits réservés