Synthesis of 1-[(Triisopropylsilyl)ethynyl]-1 lambda(3),2-benziodoxol-3(1H)-one and Alkynylation of Indoles, Thiophenes, and Anilines

Brand, Jonathan P.Waser, Jerome2012-05-182012-05-182012-05-18201210.1055/s-0031-1290589https://infoscience.epfl.ch/handle/20.500.14299/80548WOS:000303104400003An efficient procedure was developed for the synthesis of 1-[(triisopropylsilyl)ethynyl]-1 lambda(3),2-benziodoxol-3(1H)-one on a 100-mmol (36-g) scale. The benziodoxolone can be used for the gold-catalyzed direct alkynylation of indole, 2-hexylthiophene, or N,N-dibenzylaniline on a 5- to 10-mmol scale.alkynesarenescatalysisheterocyclesiodineHypervalent IodineHeterocyclesGoldChemistryReagentEbxElectrophilic AlkynylationSynthesis of 1-[(Triisopropylsilyl)ethynyl]-1 lambda(3),2-benziodoxol-3(1H)-one and Alkynylation of Indoles, Thiophenes, and Anilinestext::journal::journal article::research article