Clement, P.Ackermann, J.Sahin-Solmaz, N.Herbertz, S.Boero, G.Kruss, S.Brugger, J.2022-09-262022-09-262022-09-262022-11-1510.1016/j.bios.2022.114642https://infoscience.epfl.ch/handle/20.500.14299/191022WOS:000855162600003In this study, we compare the electrical and optical signal transduction of nanoscale biosensors based on single -walled carbon nanotubes (SWCNTs). Solution processable single-stranded (ss) DNA-wrapped SWCNTs were used for the fabrication of the distinct sensors. For electrical measurements, SWCNTs were assembled from solution onto pre-patterned electrodes by electric-field-assisted assembly in field-effect transistor (FET) configuration. A combination of micro-and nano-fabrication and microfluidics enabled the integration into a sensing platform that allowed real-time and reversible detection. For optical measurements, the near-infrared (NIR) fluorescence of the SWCNTs was acquired directly from solution. The detection of important biomolecules was investigated in high-ionic strength solution (0.5xPBS). Increase in fluorescence intensities correlated with a decrease in the SWCNTs electrical current and enabled detection of the important biomolecules dopamine, epinephrine, and ascorbic acid. For riboflavin, however, a decrease in the fluorescence intensity could not be associated with changes in the SWCNTs electrical current, which indicates a different sensing mechanism. The combination of SWCNT-based electrical and optical transduction holds great potential for selective detection of biomarkers in next generation portable diagnostic assays.BiophysicsBiotechnology & Applied MicrobiologyChemistry, AnalyticalElectrochemistryNanoscience & NanotechnologyChemistryScience & Technology - Other Topicsbiosensorscarbon nanotubeelectrical transductionmolecular recognitionnear -infrared fluorescenceneurotransmitterabsorption cross-sectionscarbon nanotubesfluorescencedopaminetext::journal::journal article::research article