Jalili, MahdiMeuli, RetoDo, Kim Q.Hasler, MartinCrow, Timothy J.Knyazeva, Maria G.2011-12-162011-12-162011-12-16201010.1111/j.1469-8986.2009.00971.xhttps://infoscience.epfl.ch/handle/20.500.14299/75432WOS:000278624600012The interhemispheric asymmetries that originate from connectivity-related structuring of the cortex are compromised in schizophrenia (SZ). Under the assumption that such abnormalities affect functional connectivity, we analyzed its correlate-EEG synchronization-in SZ patients and matched controls. We applied multivariate synchronization measures based on Laplacian EEG and tuned to various spatial scales. Compared to the controls who had rightward asymmetry at a local level (EEG power), rightward anterior and leftward posterior asymmetries at an intraregional level (1st and 2nd order S-estimator), and rightward global asymmetry (hemispheric S-estimator), SZ patients showed generally attenuated asymmetry, the effect being strongest for intraregional synchronization in the alpha and beta bands. The abnormalities of asymmetry increased with the duration of the disease and correlated with the negative symptoms. We discuss the tentative links between these findings and gross anatomical asymmetries, including the cerebral torque and gyrification pattern, in normal subjects and SZ patients.SynchronizationLaplacian EEGS-estimatorCerebral torqueGyrificationAnomalous Cerebral AsymmetryEarly-Onset SchizophreniaState-Space Analysis1St-Episode SchizophreniaHigh-RiskHandednessGyrificationMriLanguageVolumetext::journal::journal article::research article