Racine, SophieDe Nanteuil, FlorianSerrano, EloisaWaser, Jerome2014-10-232014-10-232014-10-23201410.1002/anie.201404832https://infoscience.epfl.ch/handle/20.500.14299/107798WOS:000340522700042(Carbo) nucleoside derivatives constitute an important class of pharmaceuticals, yet there are only few convergent methods to access new analogues. Here, we report the first synthesis of thymine-, uracil-, and 5-fluorouracil-substituted diester donor-acceptor cyclopropanes and their use in the indium-and tin-catalyzed [3+2] annulations with aldehydes, ketones, and enol ethers. The obtained diester products could be easily decarboxylated and reduced to the corresponding alcohols. The method gives access to a broad range of new (carbo) nucleoside analogues in only four or five steps and will be highly useful for the synthesis of libraries of bioactive compounds.annulationcatalysiscyclopropanesnucleosidesstereoselective synthesistext::journal::journal article::research article