Increase of [F-18]FLT Tumor Uptake In Vivo Mediated by FdUrd: Toward Improving Cell Proliferation Positron Emission Tomography

Viertl, DavidDelaloye, Angelika BischofLanz, BernardPoitry-Yamate, CaroleGruetter, RolfMlynarik, VladimirAmetamey, Simon M.Ross, Tobias L.Lehr, Hans-AntonAndre, Pierre-AlainPerillo-Adamer, FlorenceKosinski, MarekDupertuis, Yves M.Buchegger, Franz2011-12-162011-12-162011-12-16201110.1007/s11307-010-0368-zhttps://infoscience.epfl.ch/handle/20.500.14299/74361WOS:0002881777000163'-deoxy-3'-[F-18]fluorothymidine ([F-18]FLT), a cell proliferation positron emission tomography (PET) tracer, has been shown in numerous tumors to be more specific than 2-deoxy-2-[F-18]fluoro-d-glucose ([F-18]FDG) but less sensitive. We studied the capacity of a nontoxic concentration of 5-fluoro-2'-deoxyuridine (FdUrd), a thymidine synthesis inhibitor, to increase uptake of [F-18]FLT in tumor xenografts.[F-18]FltPetFdUrdThymidine synthesisCell proliferationCancer-PatientsF-18-Flt PetRadiolabeled IododeoxyuridineKi-67 ImmunohistochemistryGastric-CancerImaging TracerFlow-CytometryLung-TumorsChemotherapyThymidineCIBM-PETIncrease of [F-18]FLT Tumor Uptake In Vivo Mediated by FdUrd: Toward Improving Cell Proliferation Positron Emission Tomographytext::journal::journal article::research article