Moutzouri, PinelopiParuzzo, Federico M.de Almeida, Bruno SimoesStevanato, GabrieleEmsley, Lyndon2020-03-052020-03-052020-03-052020-02-1910.1002/anie.201916335https://infoscience.epfl.ch/handle/20.500.14299/166983WOS:000514245300001The typical linewidths of H-1 NMR spectra of powdered organic solids at 111 kHz magic-angle spinning (MAS) are of the order of a few hundred Hz. While this is remarkable in comparison to the tens of kHz observed in spectra of static samples, it is still the key limit to the use of H-1 in solid-state NMR, especially for complex systems. Here, we demonstrate a novel strategy to further improve the spectral resolution. We show that the anti-z-COSY experiment can be used to reduce the residual line broadening of H-1 NMR spectra of powdered organic solids. Results obtained with the anti-z-COSY sequence at 100 kHz MAS on thymol, beta-AspAla, and strychnine show an improvement in resolution of up to a factor of two compared to conventional spectra acquired at the same spinning rate.Chemistry, MultidisciplinaryChemistryh-1 nmranti-z-cosyhigh resolutionultra-fast magic-angle spinninghigh-resolution nmr100 khz masstate nmrspectrasystemstext::journal::journal article::research article