Muller, U.Steinhoff, U.Reis, L. F.Hemmi, S.Pavlovic, J.Zinkernagel, R. M.Aguet, M.2007-12-122007-12-122007-12-12199410.1126/science.8009221https://infoscience.epfl.ch/handle/20.500.14299/15436Mice lacking the known subunit of the type I interferon (IFN) receptor were completely unresponsive to type I IFNs, suggesting that this receptor chain is essential for type I IFN-mediated signal transduction. These mice showed no overt anomalies but were unable to cope with viral infections, despite otherwise normal immune responses. Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.text::journal::journal article::research article