Synthetic routes to NEtXaa(4)-cyclosporin A derivatives as potential anti-HIV I drugs

Hubler, FRuckle, TPatiny, LMuamba, TGuichou, JFMutter, MWenger, R2006-02-092006-02-092006-02-09200010.1016/S0040-4039(00)01267-3https://infoscience.epfl.ch/handle/20.500.14299/222272An efficient synthesis in 10 steps and overall yields up to 27% of NEtXaa(4)-cyclosporin A derivatives (Xaa = Leu, Val, Ile, Thr) starting from cyclosporin A is described. Biological activities of the new analogues show promising results for the design of cyclosporin derivatives exhibiting non-immunosuppressive and anti-HIV activity. (C) 2000 Elsevier Science Ltd. All rights reserved.Synthetic routes to NEtXaa(4)-cyclosporin A derivatives as potential anti-HIV I drugstext::journal::journal article::research article