Marull, MarcSchlosser, Manfred2006-03-032006-03-032006-03-03200410.1002/ejoc.200300610https://infoscience.epfl.ch/handle/20.500.14299/227023WOS:00022004840000847414-Bromo-6-fluoro-2-(trifluoromethyl)quinoline and 4-bromo-7-fluoro-2-(trifluoromethyl)quinoline were selected as model substrates to explore under what conditions regiochem. exhaustive functionalization reactions can be carried out. This goal was achieved by using trimethylsilyl entities and iodine atoms as the sole auxiliary substituents. The organolithium intermediates could be generated and the protective groups removed without impairing the bromine atom present at the 4-position. [on SciFinder (R)]Protective groups (prepn. of halogenated quinoline regioisomers using trimethylsilyl protective groups); Isomers (regioisomers; prepn. of halogenated quinoline regioisomers using trimethylsilyl protective groups); Functional groups (trimethylsilyl grouphalogenated quinoline regioisomer prepnRegioflexibility in the functionalization of multiply halogenated quinolinestext::journal::journal article::research article