Joye, NeilSchmid, AlexandreLeblebici, Yusuf2009-10-222009-10-222009-10-22200910.1016/j.neucom.2009.09.006https://infoscience.epfl.ch/handle/20.500.14299/43831WOS:000272607000031Accurate electrical models are needed to support the design of modern microelectrode arrays. The point-contact model is presented thoroughly, and an area-contact model is analytically derived in order to model the electrical characteristics of the cell-electrode interface at subcellular resolution. An optimum electrode diameter for recording the electrical activity of neurons is analytically determined at 8 um, with a cell diameter of 10 um and a typical load capacitance of 10 pF. Finally, three- dimensional tip electrodes are characterized using the area- contact model. An improvement of the electrical coupling up to 20 dB is observed for small electrodes, in simulation.Cell-electrode electrical modelExtracellular signal recordingHigh-density microelectrode arraySubcellular resolutionThree-dimensional tip electrodeElectrical modeling of the cell-electrode interface for recording neural activity from high-density microelectrode arraystext::journal::journal article::research article