Fayol, AudeZhu, Jieping2010-11-252010-11-252010-11-25200510.1021/ol0477881https://infoscience.epfl.ch/handle/20.500.14299/58466By simply heating a toluene soln. of isocyanoacetamide, amine, and aldehyde, a clean three-component reaction occurred to provide the 6-azaindolines and pyrrolidinone-fused 6-azaindolines. E.g., heating a mixt. of morpholine, heptanal, and isocyanoacetamide I gave 61% 6-azaindoline II. In this multicomponent reaction, the isocyanoacetamide reacted four times in a highly ordered manner creating three heterocyclic rings with the concurrent formation of five chem. bonds and a minimal loss of mol. wt. Heating is the only external energy required to promote this powerful complexity-generating MCR. [on SciFinder (R)]Cyclization (prepn. of 6-azaindolines and pyrrolidinone-fused 6-azaindolines by three-component reaction of isocyanoacetamidesaminesand aldehydes); Aldehydes; Amines Role: RCT (Reactant)RACT (Reactant or reagent) (prepn. of 6-azaindolines and pyrrolidinone-fused 6-azaindolines by three-component reaction of isocyanoacetamidesaminesand aldehydes); Isocyanides Role: RCT (Reactant)SPN (Synthetic preparation)PREP (Preparation)RACT (Reactant or reagent) (prepn. of 6-azaindolines and pyrrolidinone-fused 6-azaindolines by three-component reaction of isocyanoacetamidesaminesand aldehydes)azaindoline pyrrolidinone fused prepn; three component reaction isocyanoacetamide amine aldehydetext::journal::journal article::research article