Common human genetic variants and HIV-1 susceptibility: a genome-wide survey in a homogeneous African population

Petrovski, SlavéFellay, JacquesShianna, Kevin V.Carpenetti, NicoleKumwenda, JohnstoneKamanga, GiftKamwendo, Deborah D.Letvin, Norman L.McMichael, Andrew J.Haynes, Barton F.Cohen, Myron S.Goldstein, David B.2011-04-112011-04-112011-04-11201110.1097/QAD.0b013e328343817bhttps://infoscience.epfl.ch/handle/20.500.14299/66255To date, CCR5 variants remain the only human genetic factors to be confirmed to impact HIV-1 acquisition. However, protective CCR5 variants are largely absent in African populations, in which sporadic resistance to HIV-1 infection is still unexplained. We investigated whether common genetic variants associate with HIV-1 susceptibility in Africans.Common human genetic variants and HIV-1 susceptibility: a genome-wide survey in a homogeneous African populationtext::journal::journal article::research article