Alonso-Sarduy, LivanLongo, GiovanniDietler, GiovanniKasas, Sandor2014-01-092014-01-092014-01-09201310.1021/nl403361fhttps://infoscience.epfl.ch/handle/20.500.14299/99344WOS:000327111700107Cancer is a major health issue that absorbs the attention of a large part of the biomedical research. Intercalating agents bind to DNA molecules and can inhibit their synthesis and transcription; thus, they are increasingly used as drugs to fight cancer. In this work, we show how atomic force microscopy in liquid can characterize, through time-lapse imaging, the dynamical influence of intercalating agents on the supercoiling of DNA, improving our understanding of the drug's effect.DNA intercalating agentsdaunorubicinAFMlinking numbertime-lapse imagingdrug developmenttext::journal::journal article::research article