Merz, Manuel LeonardoHeinis, Christian2024-02-202024-02-202024-02-202023-12-2810.1038/s41589-023-01505-0https://infoscience.epfl.ch/handle/20.500.14299/204859WOS:001133223600002Cyclic peptides can bind challenging disease targets, but their oral application is hindered by digestion and absorption issues. We developed a versatile method for the synthesis and functional screening of vast numbers of synthetic cyclic peptides and identified peptides with high inhibitory activity, stability and oral bioavailability in rats.Life Sciences & BiomedicineDevelopment of cyclic peptides that can be administered orally to inhibit disease targetstext::journal::journal article::research article