Seiser, TobiasKamena, FaustinCramer, Nicolai2011-08-172011-08-172011-08-17200810.1002/anie.200802043https://infoscience.epfl.ch/handle/20.500.14299/70149A modular synthesis of the marine natural product largazole and related synthetic analogs is described. Largazole was prepd. in 10% overall yield through a synthetic route with a longest linear sequence of nine steps. Activity tests showed the necessity of the thiobutenyl moiety for antiproliferative activity.largazole marine natural product prepn antiproliferativecrystal structure largazole precursortext::journal::journal article::research article