Bruschini, ClaudioHomulle, HaraldCharbon, Edoardo2018-06-112018-06-112018-06-112017-02-2110.1117/12.2256247https://infoscience.epfl.ch/handle/20.500.14299/146805SPAD (single-photon avalanche diode) arrays are single-photon imagers that can provide unparalleled timeresolved sensing performance. Since their inception in standard CMOS technologies (2003), a host of architectures and target applications have been explored, ranging from simple pixel arrays, with off-chip data processing electronics, to fully integrated “smart” imagers with in-pixel time-stamping electronics and/or on-chip data processing fabric. Applications include (endoscopic) FLIM, (multi-beam multiphoton) FLIM-FRET, SPIMFCS, time-resolved Raman, NIROT, super-resolution microscopy, and PET, to name a few. We will review some representative sensors and applications, the corresponding challenges, and provide an outlook on the future of this fascinating technologyTen years of biophotonics single-photon SPAD imager applications: retrospective and outlook, Multiphoton Microscopy in the Biomedical Sciences XVIItext::conference output::conference proceedings::conference paper