Sun, JieTang, Li2024-02-212024-02-212024-02-212024-01-0210.1038/s41587-023-02061-7https://infoscience.epfl.ch/handle/20.500.14299/205012WOS:001138166100019Chimeric antigen receptor (CAR) T cells in the solid tumor microenvironment enter a partially dysfunctional state called T cell exhaustion. Interleukin (IL)-10-producing CAR T cells retain their metabolic fitness, resist T cell exhaustion and display unprecedented antitumor activity indicated by high cure rates and durable responses in mice. Clinical studies of IL-10-producing CAR T cells are underway.Life Sciences & BiomedicineMetabolically enhanced CAR T cells efficiently clear solid tumors in micetext::journal::journal article::research article