Scutelnic, ValeriuRizzo, Thomas R.2019-03-132019-03-132019-03-13201910.1021/acs.jpca.9b00527https://infoscience.epfl.ch/handle/20.500.14299/155551We combine conformer-selective, cryogenic infrared spectroscopy, quantum mechanical computations, and 18O substitution at the reducing end to determine the structural preferences of protonated glucosamine in the gas phase. Cryogenic infrared-infrared (IR-IR) double resonance spectroscopy of helium-tagged protonated glucosamine provides vibrational fingerprints of individual conformers, and 18O isotopic labeling facilitates the match with computed structures and provides a selective probe of the anomeric hydroxyl. This is key for using vibrational spectroscopy for glycan analysis and determining the generality of anomeric memory during glycosidic bond cleavage.glycansmonosaccharidesvibrational spectroscopymass spectrometrytext::journal::journal article::research article