Fellay, JacquesShianna, Kevin V.Telenti, AmalioGoldstein, David B.2011-04-192011-04-192011-04-19201010.1371/journal.ppat.1001033https://infoscience.epfl.ch/handle/20.500.14299/66555This is a crucial transition time for human genetics in general, and for HIV host genetics in particular. After years of equivocal results from candidate gene analyses, several genome-wide association studies have been published that looked at plasma viral load or disease progression. Results from other studies that used various large-scale approaches (siRNA screens, transcriptome or proteome analysis, comparative genomics) have also shed new light on retroviral pathogenesis. However, most of the inter-individual variability in response to HIV-1 infection remains to be explained: genome resequencing and systems biology approaches are now required to progress toward a better understanding of the complex interactions between HIV-1 and its human hosttext::journal::journal article::review article