Garcia-Ruiz, Beatrizde Moura, Manuel CastroMuntane, GerardMartorell, LourdesBosch, ElenaEsteller, ManelJ Canales-Rodriguez, ErickPomarol-Clotet, EdithJimenez, EstherVieta, EduardVilella, Elisabet2021-05-222021-05-222021-05-222021-05-0410.2217/epi-2021-0006https://infoscience.epfl.ch/handle/20.500.14299/178335WOS:000646728300001Aim: To investigate DDR1 methylation in the brains of bipolar disorder (BD) patients and its association with DDR1 mRNA levels and comethylation with myelin genes. Materials & methods: Genome-wide profiling of DNA methylation (Infinium MethylationEPIC BeadChip) corrected for glial composition and DDR1 gene expression analysis in the occipital cortices of individuals with BD (n = 15) and healthy controls (n = 15) were conducted. Results: DDR1 5-methylcytosine levels were increased and directly associated with DDR1b mRNA expression in the brains of BD patients. We also observed that DDR1 was comethylated with a group of myelin genes. Conclusion: DDR1 is hypermethylated in BD brain tissue and is associated with isoform expression. Additionally, DDR1 comethylation with myelin genes supports the role of this receptor in myelination.Genetics & Hereditybipolar disorderdiscoidin domain receptor 1gene expressionhuman brainmethylationmyelin genestext::journal::journal article::research article