Ozols, KristersJang, Yun-SukCramer, Nicolai2019-06-182019-06-182019-06-182019-04-1010.1021/jacs.9b02569https://infoscience.epfl.ch/handle/20.500.14299/156863WOS:000464769000019The synthesis of a set of cobalt(III)-complexes equipped with trisubstituted chiral cyclopentadienyl ligands is reported, and their steric and electronic parameters are mapped. The application potential of these complexes for asymmetric C-H functionalizations with 3d-metals is shown by the synthesis of dihydroisoquinolones from N-chlorobenzamides with a broad range of alkenes. The transformation proceeds with excellent enantioselectivities of up to 99.5:0.5 er and high regioselectivities. The observed values outperform the best rhodium(III)-based methods for this reaction type. Moreover, challenging substrates such as alkyl alkenes also react with high regio- and enantioselectivities.Chemistry, MultidisciplinaryChemistryasymmetric catalysisactivationligandsreactivitybondstext::journal::journal article::research article