A polymorphism in the HCP5 gene associated with HLA-B*5701 does not restrict HIV-1 in vitro

Yoon, WoohyunMa, Ben-JiangFellay, JacquesHuang, WeiXia, Shi-MaoZhang, RuijunShianna, Kevin V.Liao, Hua-XinHaynes, Barton F.Goldstein, David B.2011-04-192011-04-192011-04-19201010.1097/QAD.0b013e32833202f5https://infoscience.epfl.ch/handle/20.500.14299/66549A single-nucleotide polymorphism (rs2395029) in the HCP5 gene associated with HLA-B*5701 is correlated with lower HIV-1 viral set point. The two allelic forms of coding region were ectopically expressed in TZM-bl cells for an effect on HIV-1 replication. No significant HIV-1 restriction was observed in the cells with infectivity assays throughout HIV-1 life cycle, suggesting that the association of HCP5 variant with viral control is likely due to HLA-B*5701-related effect or other functional variants in the haplotype or both.A polymorphism in the HCP5 gene associated with HLA-B*5701 does not restrict HIV-1 in vitrotext::journal::journal article::research article