Bonazzi, SimoneBinaghi, MassimoFellay, CindyWach, Jean-YvesGademann, Karl2009-12-172009-12-172009-12-17201010.1055/s-0029-1218608https://infoscience.epfl.ch/handle/20.500.14299/44879WOS:000274246100011Synthetic studies towards the construction of the cyclopenta[a]indene fragment of the heptacyclic marine metabolite sporolide are reported based on a hypothetical biosynthesis. The key step of this biogenetic proposal includes a Bergman cyclization of an enediyne precursor. The enediyne target of this synthetic study was prepared by Sonogashira cross-coupling of two fragments, of which the cyclopentane fragment was prepared from cyclopentenone, Morita-Baylis-Hillman reaction, and enantioselective Sharpless dihydroxylation.cross-couplingnatural productsoxidationsstereoselective synthesistotal synthesisSynthetic Studies on the Sporolides: Exploration of the Enediyne Routetext::journal::journal article::research article