Bolmont, TristanBouwens, ArnoPache, ChristopheDimitrov, MitkoBerclaz, CorinneVilliger, MartinWegenast-Braun, B. M.Lasser, TheoFraering, Patrick2012-11-212012-11-21201210.1523/JNEUROSCI.0925-12.2012https://infoscience.epfl.ch/handle/20.500.14299/87002WOS:000310054000008We demonstrate label-free imaging of cerebral β-amyloidosis ex vivo and in a living mouse model of Alzheimer's disease using extended focus Fourier domain optical coherence microscopy (xfOCM). xfOCM provides 3D, high-resolution images of individual β-amyloid plaques in the brain parenchyma and vasculature and requires no staining of the Alzheimeric sample under investigation. xfOCM also opens the possibility to perform minimally invasive studies of β-amyloid pathology in vivo, without the use of labeling methods, which potentially confound experimental findings.text::journal::journal article::research article