Bheda, PoonamHou, JingyiAebersold, RuediAlon, UriBader, Joel S.Bardwell, LeeLiu, Edison T.Locke, James C.W.Mann, MatthiasMillar, Andrew J.Naef, FelixPilpel, YitzhakShamir, RonVitkup, Dennis2025-12-012025-12-012025-11-29202510.1038/s44320-025-00170-w2-s2.0-105022646354https://infoscience.epfl.ch/handle/20.500.14299/25649841266896As Molecular Systems Biology marks its 20th anniversary, we take this moment to reflect on two decades of discovery and innovation. Since its launch, the journal has stood at the forefront of integrating quantitative biology, computational modeling, and systems science—helping to shape how we understand complex biological systems.entruetext::journal::editorial